Self-Emulsifying Drug Delivery System (SEDDS): An Approach To Increase The Solubility Of Lipophilic Drugs
نویسندگان
چکیده
منابع مشابه
Self-Emulsifying Drug Delivery Systems (SEDDS) in Pharmaceutical Development
Volume 5 • Issue 3 • 1000130 J Adv Chem Eng ISSN: 2090-4568 ACE an open access journal Self-Emulsifying Drug Delivery Systems (SEDDS) in Pharmaceutical Development Beatriz Zanchetta1,2, Marco Vinícius Chaud3 and Maria Helena Andrade Santana1,* 1Department of Engineering of Materials and Bioprocesses, School of Chemical Engineering, University of Campinas, SP, Brazil 2Department of Research and ...
متن کاملMechanistic studies of self emulsifying drug delivery systems for the oral delivery of lipophilic drugs
Introduction Oral drug delivery is a $35 billion dollar industry [1] and the most preferred way of drug administration. However, the oral route is not possible for 50% of currently marketed drug compounds due to their low solubility in water. Forty percent of prospective drugs coming out of discovery pipelines are lipophilic compounds, which leads to difficulty in achieving acceptable oral bioa...
متن کاملFormulation development of an albendazole self-emulsifying drug delivery system (SEDDS) with enhanced systemic exposure.
The aim of the study was to develop and evaluate a self--emulsifying drug delivery system (SEDDS) formulation to improve solubility and dissolution and to enhance systemic exposure of a BCS class II anthelmetic drug, albendazole (ABZ). In the present study, solubility of ABZ was determined in various oils, surfactants and co-surfactants to identify the microemulsion components. Pseudoternary ph...
متن کاملSelf-Emulsifying Drug Delivery Systems (SEDDS) for Oral Delivery of Lipid Based Formulations - A Review
More than 60% of drugs have lipophilic nature and exhibit poor water-solubility. The dissolution is the rate limiting step in their absorption and oral bioavailability. To overcome this problem one approach to enhance dissolution is Self-Dispersing Lipid Formulations (SDLFs). Generally, an emulsified dosage form is rapidly absorbable; therefore, it makes sure that a poorly water-soluble drug is...
متن کاملDesign and Evaluation of Self-Emulsifying Drug Delivery System (SEDDS) Of Carvedilol to Improve the Oral Absorption
BACKGROUND Self-emulsifying drug delivery system is an isotropic mixture of natural or synthetic oils, non-ionic surfactants or, one or more hydrophilic solvent and co-solvents/surfactant and polymer that improve bioavailability and increase solubility of poorly-soluble drugs. OBJECTIVES This study was aimed to prepare and develop a stable formulation for self-emulsifying drug delivery system...
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ژورنال
عنوان ژورنال: American Journal of PharmTech Research
سال: 2020
ISSN: 2249-3387
DOI: 10.46624/ajphr.2020.v8.i1.007